Animal fights in the wild

Why Some People Are Immune To HIV

Why Some People Are Immune To HIV Doctors have long been mystified as to why Hiv-1 rapidly sickens some individuals, while in others the virus has difficulties gaining a foothold. Now, a study of genetic variation in HIV-1 and in the cells it infects reported by University of Minnesota researchers in this week’s issue of PLOS Genetics has uncovered a chink in HIV-1’s armor that may, at least in part, explain the puzzling difference and potentially open the door to new treatments. HIV-1 harms people by invading immune system cells known t lymphocytes, hijacking their molecular machinery to make more of themselves, then destroying the host cells-leaving the infected person more susceptible to other deadly diseases. T lymphocytes are not complete sitting ducks, however. Among their anti-virus defense mechanisms is a class of proteins known as APOBEC3S that have the ability to block the HIV-1’s ability to replicate. Not surprisingly, however, HIV-1’s has a counter defense mechanism- a protein called Vif that cons the T lymphocytes into destroying their own APOBEC3. Suspecting differential susceptibility to HIV-1 might be related to genetic variations in this system, research team led by doctoral student Eric Refsland and Reuben Harris of the University’s College of Biological Science and Medical School took a closer look. First, the researchers found that HIV-1 infection boosts the production of one kind of APOBEC3, APOBEC3H- suggesting it’s a key player in fighting back. Then, using an experimental technique known as separation of function mutagenesis, they discovered that different people have different strengths /potencies of APOBEC3H, with some proteins expressed stably and others inherently unstable. The stable variations, the researchers found, were able to successfully limit HIV-1’s ability to replicate if the infecting virus had a weak version of Vif- but not for HIV-1 viruses that had strong Vif. “This work shows that the competition between the virus and the host is still ongoing,” Refsland says. “The virus hasn’t completely perfected its ability to replicate in humans.” Armed with this clearer picture of the multifaceted interactions between Vif and APOBEC3, Harris says, the next step is to figure out how to stop Vif from disabling the APOBEC3 enzymes. “One could imagine drugs that stop Vif from binding with APOBEC,” he said. “This is a bonafide HIV killing pathway, and we just have to devise clever ways to activate it in infected persons. Such an approach could indefinitely suppress virus replication, and even result in curing it.”

Billy Goat mating with a Dog(bitch)

incredible stories will not seize from the surface of the earth, ' just this morning roughly at about 10:35am on this day 16th of January 2015, a brother and friend named Moses, an Electrician and his apprentice storm my room buzzing with awe and excitement, " have you heard, he asked?" i was so surprised and i told him to say it or swallow it forever, to my greatest shock he exclaimed, there is a Billy goat that was reported mating with a dog just a pole distance from my home. i couldn't contain the news that rushed out to go and take look at this incredible scene, although by the time i got there the dog has been locked inside the compound by its owner, Mr Ephraim. since the goat was still lurking around i decided to contact Mr Ephraim on the next line of action. i told him even if we are going to kill both the dog and the goat, i should be able to get the live act not just the story, to this he agreed so i shall bringing you more story on this